Perhaps, if it turns out transhumanism (or, rather, its polyspecific analog, transsophontism) is the development path all species end up taking once they have the ability to do so, the problem is that once they’ve spent much time and effort on engineering themselves into ever-more brilliant and beautiful forms, they rest of the universe becomes simply too unbearably stupid and ugly to interact with…

And so they don’t.

And they become pretty damn good at hiding from SETI searches, too, because the last thing they want is any of these ugly morons turning up on their doorstep.

Simply revolting, sweetie.