Culture Clash: All. The. Time.
The really big ones, like between the Imperials and the Hope Hegemony or the Equality Concord at one end of the spectrum, and between them and the Rim Free Zone at the other, and between the Photonic Network and all meat intelligences everywhere, etc., are just the most obvious, but when you wander away from the rough consensus of the CSP, CEP, and trade protocols of the Accord, well, these are cultures which may not be completely alien to each other, folks, but they can get pretty close. What were you expecting?