Operator Incompatibility: This does happen a fair bit, given the sheer number of species and clades in the setting, but less than you might think.  After all, given the potential markets, there are entire professions which exist purely in order to work out ways to overcome this sort of user interface problem – or, at the very least, make it easy to reconfigure the user interface, dynamically if possible, for users with alternative senses and/or manipulators. (And enough devices are network-controlled these days that it can often be cured with no more than a software patch.)